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Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

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Published on: April 27, 2017

Calcium-Enriched Magnetic Core-Shell Mesoporous Nanoparticles for Potential Application in Bone Regeneration.

Despoina Kordonidou^1,2, Georgia K Pouroutzidou^1,2, Nikoletta Florini¹

¹School of Physics, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

Nanomaterials (Basel, Switzerland)

|December 24, 2025

Summary

Magnetite (Fe3O4) nanoparticles coated with calcium-enriched mesoporous silica (mSiO2) show promise for bone regeneration. These core-shell nanoparticles exhibit good biocompatibility and osteogenic differentiation potential for tissue engineering applications.

Keywords:

Fe3O4 nanoparticles TEM VSM biocompatibility bone regeneration calcium doping magnetic core–shell nanoparticles mesoporous silica

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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

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Published on: July 27, 2022

Area of Science:

Biomaterials science
Nanotechnology
Materials chemistry

Background:

Magnetite (Fe3O4) nanoparticles are biocompatible and easily functionalized.
Mesoporous silica (mSiO2) coatings provide high surface area and tunable chemistry for applications like drug loading.
Enhancing nanoparticle bioactivity is crucial for bone regeneration and tissue engineering.

Purpose of the Study:

To synthesize and characterize Fe3O4 nanoparticles coated with calcium ion (Ca2+)-enriched mSiO2 shells.
To evaluate the potential of these core-shell nanoparticles for bone regeneration and tissue engineering.
To optimize synthesis routes for improved shell formation and properties.

Main Methods:

Synthesis of Fe3O4 nanoparticles and their coating with mSiO2 shells.
Characterization using VSM, TEM, and other techniques to analyze structure, magnetism, and size.
MTT assays and cell differentiation studies to assess biocompatibility and osteogenic potential.

Main Results:

Optimized Fe3O4/mSiO2/Ca2+ core-shell nanoparticles exhibited a mesoporous structure (type IVb).
Calcium incorporation slightly altered magnetic properties but maintained core crystallinity and particle size (11.68-13.56 nm).
Non-toxicity was confirmed by MTT assays, with mild cytotoxicity only at high Ca2+ concentrations.
The nanoparticles induced osteogenic differentiation in human periodontal ligament cells.

Conclusions:

Fe3O4/mSiO2/Ca2+ core-shell nanoparticles possess favorable magnetic, structural, and biological properties.
These nanoparticles are promising candidates for bone-related biomedical applications, particularly in bone regeneration and tissue engineering.
The study highlights the potential of functionalized magnetic nanoparticles for advancing regenerative medicine.