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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Firoza Z Lussier1, Guilherme Povala1, Guilherme Bauer-Negrini1

  • 1University of Pittsburgh, Pittsburgh, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The HEAD study is generating a comprehensive dataset of tau-PET tracers (MK-6240, Flortaucipir, RO948, PI-2620) to standardize in vivo tau pathology quantification. This research will harmonize tracer outcomes and develop tools for generalizing findings across studies.

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Standardizing in vivo tau pathology quantification using tau-PET tracers presents challenges due to tracer-specific characteristics.
  • The HEAD study was initiated to address these challenges by creating a leading longitudinal head-to-head dataset.

Purpose of the Study:

  • To harmonize outcomes from multiple tau-PET tracers (MK-6240, Flortaucipir, RO948, PI-2620).
  • To develop tools for generalizing tau-PET findings across different studies and clinical trials.
  • To provide an update on the progression of the HEAD study.

Main Methods:

  • A multicentric study involving nine performance sites and aiming for 620 participants across different age groups and cognitive classifications.
  • Standardized clinical assessments, blood collection for biomarker banking, and MRI acquisition.
  • Head-to-head tau-PET imaging with at least two tracers per participant, alongside amyloid-PET, with uniform data processing.
  • Centralized databasing by LONI and blood biorepository services by NCRAD, with 18-month follow-up procedures.

Main Results:

  • Enrolled 679 participants over 26 months, exceeding the target by 9.5%.
  • Collected 1,489 head-to-head tau-PET scans from 551 participants at their initial timepoint.
  • Initiated longitudinal data collection in 95 participants, with 18-month follow-up scans underway.
  • Characterized the cohort including demographics, APOEε4 carriership, and plasma biomarker distribution.

Conclusions:

  • The HEAD study cohort is crucial for optimizing Alzheimer's disease (AD) imaging biomarkers.
  • Ongoing cross-sectional and longitudinal data collection, alongside plasma biomarker measurements, will yield significant insights.
  • Findings from the HEAD cohort will offer essential guidance for the clinical application of tau-PET tracers in AD research.