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Sepsis-induced delirium may worsen Alzheimer

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Area of Science:

  • Neuroscience
  • Pathology
  • Gerontology

Background:

  • Delirium, an acute cognitive dysfunction, is a severe sepsis complication.
  • Alzheimer's disease (AD) involves chronic cognitive decline and tau protein accumulation.
  • Emerging evidence links sepsis-induced delirium to accelerated AD tau pathology.

Purpose of the Study:

  • To investigate the impact of sepsis-induced delirium on tau pathology.
  • To utilize a long-term sepsis model in P301S mice expressing mutant human tau.

Main Methods:

  • Wild-type and P301S mice underwent sepsis induction via cecal slurry (CS) or saline control.
  • Behavioral tests, electroencephalography (EEG), and postmortem analyses (tau, microglia, inflammation) were performed.
  • EEG evaluated brain activity to characterize a delirium-like state.

Main Results:

  • CS-treated mice showed increased depressive-like behavior.
  • P301S mice, especially those treated with CS, exhibited increased phosphorylated tau and microglial activation.
  • EEG data differentiated between sick and recovered mice.

Conclusions:

  • Preliminary findings suggest sepsis-induced delirium may advance tau pathology in P301S mice.
  • Increased phosphorylated tau and microglial activation indicate potential long-term effects of sepsis on AD-like pathology.
  • Further research is needed to fully understand the sepsis-delirium-tau pathology relationship.