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Pilot Retrospective Evaluation of a Balancing and Optimizing Injection Pattern for the Frontalis Muscle Using

Konstantin Frank¹, Lukas Prantl¹, Vanessa Brebant¹

¹Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

|December 24, 2025

Summary

This summary is machine-generated.

A new structured injection technique for forehead lines using letibotulinumtoxinA shows promising results. This method aims to improve forehead wrinkles and minimize eyebrow descent, offering a consistent approach to upper facial rejuvenation.

Keywords:

LEBO forehead injection forehead lines frontalis neuromodulator

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Area of Science:

Aesthetic Medicine
Facial Anatomy
Neuromodulator Injections

Background:

Aging causes upper facial changes like forehead lines and eyebrow ptosis.
Anatomical variations in the frontalis muscle complicate neurotoxin treatments.
Standardized approaches are needed for consistent forehead rejuvenation.

Purpose of the Study:

To introduce and evaluate a structured injection pattern for forehead lines.
To assess the efficacy and safety of this technique using letibotulinumtoxinA.
To minimize procedural challenges associated with frontalis muscle variability.

Main Methods:

Retrospective analysis of 24 patients treated with a standardized injection scheme.
Utilized letibotulinumtoxinA with concomitant glabellar treatment.
Assessed forehead line severity and quantified skin displacement using 3D imaging.

Main Results:

Significant reduction in dynamic and static forehead lines observed within two weeks.
High percentage of patients achieved substantial improvement in line severity.
The structured approach demonstrated a low complication rate with minimal need for touch-ups.

Conclusions:

The structured injection pattern appears to be a consistent method for treating forehead lines.
This technique shows potential for effective upper facial rejuvenation with letibotulinumtoxinA.
Further prospective studies are warranted to validate these preliminary findings.