Related Experiment Video
Updated: Jan 7, 2026
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Transient Hepatitis B Surface Antigenemia Following Immunization with the Adjuvanted Hepatitis B Vaccine Fendrix®
Virginia Fernández-Espinilla1,2, Paula Ardura-Agudín3, Daniel Leonardo Sánchez-Carmona2
1Department of Preventive Medicine and Public Health, University of Valladolid, 47005 Valladolid, Spain.
Background:
Serological screening for HBV is standard in hemodialysis, and vaccination is recommended for non-immune patients.
Objective:
To determine the cause of positive HBsAg detected shortly after vaccination.
Methods:
We conducted a retrospective study in a tertiary hemodialysis unit. Patients with HBsAg reactivity after receiving the adjuvanted HBV vaccine (Fendrix®) were followed with serial serology until HBsAg clearance.
Results:
Forty-four patients were monitored; seven (15.9%) tested HBsAg-positive 1-7 days post-vaccination, with no evidence of acute hepatitis, prior HBV infection, transplantation, or chronic immunosuppression. Six cleared HBsAg on repeat testing; one remained positive until day 19, with HBsAg as the only marker.
Conclusions:
Vaccine-related transient HBsAg antigenemia can occur shortly after immunization. Recognizing this phenomenon and timing routine serology appropriately can prevent misinterpretation and unnecessary workups in CKD patients.
Related Concept Videos
01:51Vaccinations
01:22Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
00:42Cross-reactivity
01:26Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...