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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anna-Katharine Brem1, Emma Poon1, Marie-Christine Fritzsche2

  • 1King's College London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study addresses ethical challenges in digital biomarker (DBM) research using a case study of the RADAR-AD project. It offers practical recommendations for ethical conduct in DBM research, from conception to sustainability.

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Area of Science:

  • Digital Health
  • Biomedical Informatics
  • Ethical, Legal and Social Implications (ELSI)

Background:

  • Digital biomarkers (DBMs) leverage technology for health monitoring but present ethical challenges.
  • Practical guidelines for ethical DBM research are scarce.
  • The RADAR-AD project's ethical challenges inform practical recommendations.

Purpose of the Study:

  • To identify and address ethical challenges in digital biomarker research.
  • To provide practical recommendations for ethical conduct in DBM studies.
  • To enhance participant respect, data management, and sustainability in DBM research.

Main Methods:

  • A case study approach using the RADAR-AD project (N=237).
  • Involved a cross-sectional observational study with digital technologies (smartphone apps, wearables, sensors).
  • Focused on participant respect and feedback/sustainability, using focus groups and a patient advisory board.

Main Results:

  • Participant respect enhanced through participatory approaches, clear informed consent, and flexible protocols.
  • Balancing privacy, burden, and accessibility is crucial for long-term data collection.
  • Consumer-grade feedback improves adherence and security; sustainability requires regulatory advice and data sharing.

Conclusions:

  • The RADAR-AD case study highlights key ethical challenges in digital biomarker research.
  • Practical recommendations are provided for ethical DBM research, from conception to sustainability.
  • Addressing ethical considerations is vital for the responsible advancement of DBM research.