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Updated: Jan 7, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Hydrosilafluorenes as Recyclable Coupling Reagents for Direct Amidation of Carboxylic Acids with Amines
Fawwaz Azam1, Brigida V Fernandes1, Clive A Boateng1
1Department of Chemistry & Biology, Toronto Metropolitan University, Toronto, Ontario M5B 2K3, Canada.
Abstract:
We have discovered both 9-methyl- and 9-phenyl-9H-9-silafluorene as effective reagents for direct amidation. The protocol is performed under open-air conditions without rigorous exclusion of moisture, producing amides in high yields with only H2 and disiloxane as byproducts. The disiloxane byproduct can be reduced in a separate step to recycle the silafluorenes. This breakthrough represents the first example of a recyclable organosilane coupling reagent and is a significant step toward developing greener amidating agents.
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