Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lifespan normative modeling of brain microstructure.

Nature communications·2026
Same author

Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavior.

Nature communications·2026
Same author

Sociability and whole-brain resting-state connectivity.

Scientific reports·2026
Same author

Normative age-related structural brain deviations underlying psychopathology, cognitive impairment and neurological soft signs in schizophrenia spectrum disorders.

Translational psychiatry·2026
Same author

Normative modeling of MEG brain oscillations across the human lifespan.

Communications biology·2026
Same author

AI in Mental Health Care-Opportunities and Risks Beyond Large Language Models.

JAMA psychiatry·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Kirsten W R Schroder1, Enrico Premi2, Valeria Bracca3

  • 1Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Frontotemporal dementia (FTD) patients show significant neuroanatomical dissimilarity compared to healthy individuals. This heterogeneity is particularly pronounced in specific cortical and subcortical regions, aiding in understanding FTD subtypes.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

Area of Science:

  • Neuroscience
  • Radiology
  • Genetics

Background:

  • Frontotemporal dementia (FTD) is a complex neurodegenerative disease with variable symptoms and pathology.
  • Diagnosing and predicting prognosis in FTD is challenging due to its heterogeneous nature.
  • Novel neuroanatomical modeling enables the quantification of individual brain deviations from normative data.

Purpose of the Study:

  • To quantify patterns of neuroanatomical dissimilarity in patients with sporadic FTD.
  • To identify specific brain regions exhibiting significant deviations in FTD subtypes.
  • To establish a baseline for individual prognosis and diagnosis in FTD.

Main Methods:

  • T1-weighted brain MRI scans from 355 participants (116 healthy controls, 197 behavioral variant FTD, 42 semantic variant PPA) were analyzed.
  • Cortical thickness and subcortical volumes were extracted and compared against a normative model derived from ~58,000 healthy individuals.
  • Regions with a z-score <-1.96 were identified as outliers, indicating significant dissimilarity.

Main Results:

  • Both behavioral variant FTD (bvFTD) and semantic variant PPA (svPPA) groups showed significantly greater cortical and subcortical dissimilarity than healthy controls.
  • The right inferior temporal gyrus was most affected in bvFTD (54% outliers).
  • The left temporal gyri (>83%) and left amygdala/hippocampus (64-67%) showed the highest proportion of outliers in svPPA.

Conclusions:

  • Patients with bvFTD and svPPA exhibit substantial heterogeneity in brain structure compared to healthy individuals.
  • Specific regions, including the right inferior temporal gyrus and left lateral temporal gyrus, are key areas of dissimilarity.
  • Further research will explore other FTD variants and clinical correlations.