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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Biomarkers.

Meenakshi Kaushik1, Manjari Tripathi2, Rima Dada2

  • 1All India Institute of Medical Sciences, New Delhi, Delhi, Delhi, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study shows that a 12-week yoga intervention significantly improved cognitive function and mood in Alzheimer's disease (AD) patients. Yoga also positively impacted key biomarkers, reducing inflammation and oxidative stress.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Integrative Medicine

Background:

  • Alzheimer's disease (AD) is characterized by cognitive decline, neuroinflammation, and synaptic dysfunction.
  • Current therapeutic strategies for AD have limitations.
  • Exploring non-pharmacological interventions is crucial for managing AD symptoms.

Purpose of the Study:

  • To investigate the effects of a 12-week yoga intervention on cognitive function in AD patients.
  • To assess the impact of yoga on mood, AD biomarkers, inflammatory responses, and oxidative stress.
  • To explore correlations between cognitive improvements and changes in biomarkers.

Main Methods:

  • A 12-week yoga intervention was administered to 30 AD patients and 20 healthy controls.
  • Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and Geriatric Depression Scale (GDS).
  • Biomarkers including amyloid-beta (Aβ), pTau proteins, APOE, inflammatory markers (IL-6, TNF-α, etc.), and oxidative stress (8-OHdG) were measured.

Main Results:

  • AD patients showed significant improvements in MoCA scores and reductions in GDS scores post-intervention.
  • Cognitive domains like language, attention, and memory were enhanced.
  • Biomarker analysis revealed reductions in Aβ-40, pTau 181, pTau 217, CRP, APOE, and 8-OHdG, with increases in Aβ-42 and BDNF.

Conclusions:

  • Yoga intervention significantly enhanced cognition and mood in AD patients.
  • The intervention led to favorable changes in AD biomarkers, reducing inflammation and oxidative stress.
  • Findings support yoga as a promising therapeutic strategy for Alzheimer's disease.