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Related Concept Videos

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Casper de Boer1,2, Rosanne L van den Berg1,2,3, Marissa D Zwan1,2

  • 1Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Automated speech analysis shows subtle changes in cognitively normal adults with amyloid-beta pathology. These findings suggest connected speech can be a digital biomarker for early Alzheimer's disease detection.

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Area of Science:

  • Neuroscience
  • Digital Health
  • Biomarkers

Background:

  • Connected speech analysis is an emerging digital biomarker for Alzheimer's disease (AD).
  • Fine-grained speech analysis may detect subtle cognitive deficits in early AD stages.
  • This study investigates speech features in relation to amyloid-beta (Aβ) pathology in cognitively normal individuals.

Purpose of the Study:

  • To identify reliable acoustic and linguistic speech features.
  • To examine the association between amyloid-beta (Aβ) pathology and longitudinal connected speech.
  • To explore the potential of connected speech as a digital biomarker for preclinical AD.

Main Methods:

  • Included 50 cognitively normal adults (23 Aβ-positive).
  • Utilized a five-day remote speech assessment repeated over 24 months.
  • Analyzed acoustic and linguistic features using linear mixed models.

Main Results:

  • Identified 10 acoustic and 8 linguistic features with good test-retest reliability.
  • Observed trends of higher pause-to-word and pronoun-to-noun ratios in Aβ-positive individuals.
  • Found longitudinal differences in pause measures, with more pauses in Aβ-positive individuals over time.

Conclusions:

  • Amyloid-beta pathology is associated with altered connected speech metrics in healthy adults.
  • Remote, multi-day speech assessments show potential as digital biomarkers for preclinical AD.
  • These findings support the use of speech analysis in observational studies and decentralized trials for early AD detection.