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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Theresa M Harrison1, Yishu Chao1, Trevor A Chadwick1

  • 1University of California, Berkeley, Berkeley, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

White matter hyperintensities (WMH) are linked to age, sex, and ethnicity, and associate with beta-amyloid burden in older adults. APOE genotype influences this relationship in men, highlighting complex interactions in Alzheimer's disease (AD) research.

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Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Research
  • Biomarker Analysis

Background:

  • White matter hyperintensities (WMH) are recognized cardiovascular disease biomarkers.
  • WMH may also correlate with Alzheimer's disease (AD) pathology.
  • Investigating WMH in relation to AD biomarkers and demographic factors is crucial.

Purpose of the Study:

  • To examine the association between WMH volume and AD biomarkers.
  • To explore demographic and genetic factors influencing WMH.
  • To understand the interplay between WMH, AD pathology, and individual characteristics.

Main Methods:

  • Utilized harmonized PET and MR imaging pipelines across four diverse cohorts (ADNI, HABS-HD, POINTER, SCAN).
  • Quantified total WMH volume and global beta-amyloid (Aβ) burden (centiloids).
  • Analyzed associations with age, sex, APOE genotype, and ethnoracial group.

Main Results:

  • Greater WMH volume correlated with older age, female sex, and specific ethnoracial groups.
  • Significant associations between WMH volume and Aβ burden were observed across most cohorts.
  • APOE genotype moderated the Aβ-WMH relationship in men, but not women.

Conclusions:

  • Total WMH volume is associated with demographic factors and Aβ burden.
  • The interaction between AD pathology and participant characteristics in driving white matter disease requires further investigation.
  • Future research will focus on regional WMH, particularly posterior regions, for stronger Aβ associations.