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Decarboxylative 3-Indole Methylenation of 4-Aminocoumarin and Application in the Synthesis of Fused Polycyclic
Yu Han1,2, Pengcheng Guan2, Yujie Qu2
1Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Abstract:
The decarboxylative indole methylenation of 4-aminocoumarins in the C3-site has been realized with copper promotion using 3-indolyl acetic acids as reaction partners. In addition to providing a practical method for the synthesis of indole methylene-functionalized 4-aminocoumarins, the metal-free intramolecular amination and aromatization have been achieved for the synthesis of complex pentacyclic compounds, namely, coumarin-fused α-carbolines, with broad scope and generally excellent efficiency.
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