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Structure basis for the activation of KCNQ2 by endogenous and exogenous ligands

Yiwen Zhao1, Zhenni Yang2, Sai Shi3

  • 1Department of Pharmacology, Hebei Medical University, The Key Laboratory of New Drug Pharmacology and Toxicology of Hebei Province, The Collaboration Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Disease of Hebei Province, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China.

Cell Reports
|December 24, 2025
PubMed

Keywords:
CP: molecular biologyCP: neuroscienceKCNQ2PIP(2)QO-58QO-83cryo-EM sructuremechanism of ligand actvation

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