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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jun Shen1,2, Sisi Peng3, Juan Du2

  • 1Changhai hosptial, Naval Medical University, Shanghai, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Cognitive dysfunction in moyamoya disease (MMD) is linked to significant changes in serum metabolites. This study reveals widespread metabolic alterations associated with impaired cognition in MMD patients.

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Area of Science:

  • Neuroscience
  • Metabolomics
  • Biochemistry

Background:

  • Cognitive dysfunction is a prevalent symptom in moyamoya disease (MMD).
  • The underlying mechanisms, especially serum metabolite changes, remain under-investigated.
  • This study explores metabolic profiles in MMD patients to understand cognitive impairment.

Purpose of the Study:

  • To analyze serum metabolic profiles in MMD patients using untargeted metabolomics.
  • To investigate the relationship between metabolic alterations and cognitive function in MMD.

Main Methods:

  • Thirty MMD patients and ten healthy controls were assessed using cognitive tests (MoCA, HVLT-R).
  • Serum samples underwent liquid chromatography-tandem mass spectrometry (LC-MS/MS) for metabolomics analysis.
  • Correlation analyses examined the link between metabolites and cognitive performance.

Main Results:

  • MMD patients exhibited significant impairments in overall cognition and specific domains like memory and recall.
  • 142 serum metabolites were significantly altered in MMD patients, with 120 upregulated and 22 downregulated.
  • Alterations were observed in bile acid, amino acid, lipid, and purine metabolism, indicating complex metabolic dysregulation.

Conclusions:

  • Cognitive dysfunction in MMD is associated with significant serum metabolic changes.
  • Altered metabolites suggest a role in the pathophysiology of MMD-related cognitive impairment.
  • These findings emphasize the need for integrated management of cognitive function in MMD.