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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Fabian Hirsch1, Lukas Frontzkowski1,2,3, Sebastian Roemer-Cassiano1,4,5

  • 1Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Bavaria, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
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Summary
This summary is machine-generated.

Brain network hubs influence Alzheimer's Disease (AD) progression. Efficient communication from tau pathology epicenters to connector hubs amplifies amyloid's effect on tau spread and cognitive decline in AD patients.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Network Science

Background:

  • Tau pathology is a key driver of neurodegeneration and cognitive decline in Alzheimer's Disease (AD).
  • Preclinical models suggest tau spreads transsynaptically between connected neurons.
  • Brain functional network topology may influence the dynamics of tau spreading.

Purpose of the Study:

  • To investigate whether functional brain hubs accelerate tau spread in AD.
  • To determine if communication efficiency from tau epicenters to specific hub types (connector vs. local) impacts tau accumulation and cognitive decline.

Main Methods:

  • Analysis of longitudinal tau/amyloid-PET and cognitive data from ADNI/A4 cohorts (n=325/220).
  • Modeling connectional efficiency from subject-level tau epicenters to connector and local hubs using structural/functional connectivity templates.
  • Robust regression to test the association between hub communication efficiency, tau accumulation, cognitive decline, and tau dissemination.

Main Results:

  • Higher baseline amyloid-PET accelerated global tau-PET increases, moderated by communication efficiency to connector hubs (ADNI/A4: β=0.31/0.40, p<0.001/0.03).
  • Stronger epicenter communication to connector hubs amplified amyloid's effect on tau accumulation rates.
  • This interaction also predicted faster cognitive decline (ADNI/A4: β=-0.49/-0.34, p<0.001/0.04) and greater tau dissemination across networks (ADNI/A4: β=0.6/0.36, p<0.001/0.04).

Conclusions:

  • Brain network topology significantly shapes tau accumulation and cognitive trajectories in AD.
  • Enhanced communication between tau epicenters and connector hubs amplifies amyloid-related tau spread.
  • The brain's network architecture critically modulates tau aggregation and disease progression in Alzheimer's Disease.