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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Ziad S Saad1, Ritobrato Datta1, Maggie Fedgchin2

  • 1Johnson & Johnson, San Diego, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Positron Emission Tomography (PET) imaging reveals how tau pathology in early Alzheimer's disease (AD) impacts specific cognitive domains. These findings link tau tangles to distinct cognitive deficits, aiding in understanding AD progression.

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Posdinemab, an anti-phosphorylated tau antibody, is being investigated for early Alzheimer's Disease (AD).
  • The Auτonomy trial (NCT04619420) included participants with mild cognitive impairment or mild AD dementia and intermediate tau levels.
  • Tau levels were pre-screened with a plasma assay and confirmed using tau Positron Emission Tomography (PET).

Purpose of the Study:

  • To analyze voxelwise associations between Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) cognitive domains and tau PET.
  • To reconstruct a brain-wide map illustrating the relationship between cognitive domains and tau pathology.

Main Methods:

  • Quantified neurofibrillary tangle levels using 18F-MK-6240 Standardized Uptake Value Ratio (SUVR) in 422 participants.
  • Aligned SUVR volumes to Montreal Neurological Institute space and smoothed within a gray matter mask.
  • Computed associations using Spearman rank correlation and generated a domain preference map based on ranked domain associations.

Main Results:

  • Significant correlations between tau PET and cognitive domains were observed across most of the brain, excluding the visuospatial domain.
  • Visuospatial domain correlated with right occipital cortex; Language with left temporal, parietal areas.
  • Delayed-memory associated with temporal, cingulate, insula, hippocampus; Attention with occipital, precuneus, frontal areas; Immediate-memory with frontal, precuneus, temporal areas.

Conclusions:

  • Mapped the impact of tau pathology on specific cognitive domains in early AD using spatially unbiased tau PET analysis.
  • The generated maps align with established brain functional organization.
  • Demonstrated a clear association between the presence and location of tau tangles and an individual's cognitive profile.