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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Gulam Mahfuz Chowdhury1, Khalid Saifullah1, Arnold M Evia2

  • 1Illinois Institute of Technology, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The Arterial Health and Aging Brain (AHAB) study found that the Arterial Health and Aging Brain (AHAB) score is not associated with Alzheimer's pathology but is linked to axonal injury in cerebral small vessel disease (CSVD). This supports AHAB as a specific marker for CSVD.

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Area of Science:

  • Neurology
  • Radiology
  • Biomarker Research

Background:

  • Intracranial arteriolosclerosis is a key factor in cerebral small vessel disease (CSVD), impacting brain health and cognition.
  • Arterial Health and Aging Brain (AHAB) score is a novel MRI marker for in-vivo arteriolosclerosis detection.
  • Plasma biomarkers like phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) indicate Alzheimer's disease (AD) and axonal damage, respectively.

Purpose of the Study:

  • To investigate the association between the Arterial Health and Aging Brain (AHAB) score and plasma biomarkers p-tau217 and NfL.
  • To determine if AHAB scores are influenced by Alzheimer's pathology.
  • To assess the relationship between AHAB scores and axonal injury.

Main Methods:

  • 202 participants with no or mild cognitive impairment from four aging cohort studies were included.
  • In-vivo MRI (3 Tesla) using MPRAGE, FLAIR, and DTI sequences was performed to calculate AHAB scores.
  • Plasma p-tau217 and NfL levels were measured; linear regression analyzed associations, controlling for demographics and scan parameters.

Main Results:

  • No significant association was found between AHAB scores and p-tau217 levels, indicating independence from Alzheimer's pathology.
  • A strong positive association was observed between AHAB scores and NfL levels, suggesting a link to CSVD-related axonal injury.

Conclusions:

  • AHAB scores are not influenced by co-occurring Alzheimer's pathology in older adults.
  • Higher AHAB scores correlate with increased axonal injury, as indicated by elevated NfL levels.
  • These findings support the utility of AHAB as a specific MRI marker for arteriolosclerosis and CSVD.