Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frontotemporal lobar degeneration in a patient carrying a pathogenic PABPN1 expansion.

Neuroradiology·2026
Same author

Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency.

Nature structural & molecular biology·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

TAS2R38-Linked MGAM Expression in Alzheimer's Disease: A Novel Target for Precision Drug Repurposing.

medRxiv : the preprint server for health sciences·2025
Same author

Evaluation of self-mediated alternatives for risk testing education and return of results (eSMARTER) study: A randomized study of methods for returning <i>APOE</i> and pTau-217 results.

Alzheimer's & dementia (New York, N. Y.)·2025
Same author

In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Kathryn L Ghisays1, Deborah Brostrom2, Robert J Bauer1

  • 1Banner Alzheimer's Institute, Phoenix, AZ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The Arizona APOE Cohort Study established a longitudinal cohort of over 300 individuals to investigate the impact of Apolipoprotein E (APOE) genotype on Alzheimer's disease (AD) risk. Findings show a clear correlation between APOE4 allelic dose and increased amyloid PET positivity, crucial for AD prevention strategies.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Genetics
  • Biomarkers

Background:

  • Apolipoprotein E (APOE) is the primary genetic risk factor for Alzheimer's disease (AD).
  • APOE exhibits three common alleles (2, 3, 4) influencing AD risk across six genotypes.
  • The Arizona APOE Cohort Study aims to clarify APOE's role in AD predisposition and protection.

Purpose of the Study:

  • To establish a longitudinal cohort of cognitively unimpaired individuals stratified by APOE genotype and age.
  • To investigate the impact of APOE4 and APOE2 allelic dose on AD risk and protection.
  • To inform the design of AD secondary and primary prevention therapies.

Main Methods:

  • Recruited over 300 participants (50-90 years old) across the US.
  • Collected extensive data including cognitive tests, clinical assessments, amyloid and tau PET scans, MRI, CSF, plasma, and DNA.
  • Longitudinal assessments (clinical, imaging, CSF) every 2 years; annual blood draws; whole genome sequencing.

Main Results:

  • 303 participants completed baseline assessments (mean age 68 years, 65% female).
  • Cohort includes diverse APOE genotypes (2/2 to 4/4), with 17% from underrepresented groups.
  • Amyloid PET positivity increased with APOE4 dose, ranging from 6% in 2/2 to 52% in 4/4 genotypes.

Conclusions:

  • The Arizona APOE Cohort provides a valuable resource for AD research.
  • Data and samples are available to collaborators to study APOE variants and AD.
  • Findings contribute to understanding AD pathogenesis and developing prevention strategies.