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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Marco Öchsner¹, Matthias Brendel², Nicolai Franzmeier³

¹LMU, München, Bavaria, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 24, 2025

Summary

This summary is machine-generated.

Microglial activation increases in Alzheimer's disease spectrum (ADS) and shows an inverse correlation with tau accumulation, suggesting a potential early role in the disease process.

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Area of Science:

Neuroscience
Neuroinflammation
Alzheimer's Disease Research

Background:

Microglial activation is observed to mirror tau accumulation in highly connected brain regions.
The precise relationship between microglial activation and tau pathology in Alzheimer's disease spectrum (ADS) remains unclear.

Purpose of the Study:

To investigate longitudinal changes in microglial activation in individuals with ADS compared to healthy controls (HC).
To determine if microglial activation changes are associated with tau levels and functional connectivity (FC).
To explore the relationship between microglia and tau across different clinical dementia rating (CDR) groups.

Main Methods:

Longitudinal study (ActiGliA) involving ADS and HC participants.
Utilized [18F]GE-180 (TSPO) PET for microglial activation and resting-state fMRI for FC.
Follow-up TAU-PET and TSPO-PET scans were acquired after 18 months.

Main Results:

Microglial activation (TSPO ratios) increased longitudinally in ADS participants compared to HC.
Increased microglial activation in ADS was negatively correlated with tau levels and positively with FC distance from tau hotspots.
Advanced stages of ADS showed increased TSPO SUVRs, with tau levels better predicted by earlier microglial activation.

Conclusions:

Microglial activation increases in ADS and exhibits an inverse correlation with tau accumulation.
Observed spatial and temporal patterns suggest microglial activation may precede tau accumulation in Alzheimer's disease.
Findings highlight the dynamic interplay between neuroinflammation and tau pathology in ADS progression.