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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Biomarkers.

Hak Young Rhee1, Geon-Ho Jahng1, Jin Yong Lee1

  • 1Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Cerebral blood flow (CBF) is higher in individuals with healthy kidney function (high eGFR) and correlates positively with eGFR. This suggests CBF may serve as an early indicator of brain health changes related to kidney function.

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Area of Science:

  • Neuroscience
  • Nephrology
  • Vascular Biology

Background:

  • Cerebral blood flow (CBF) is vital for brain function and a key indicator of brain health.
  • Estimated glomerular filtration rate (eGFR) assesses kidney function and disease stage.
  • Both CBF and eGFR reflect the vascular health of the brain and kidneys, respectively.

Purpose of the Study:

  • To investigate the relationship between cerebral blood flow (CBF) and estimated glomerular filtration rate (eGFR) in healthy adults.
  • To determine if CBF can serve as an early biomarker for changes in brain integrity related to kidney function.

Main Methods:

  • 785 healthy middle-aged and older adults were enrolled.
  • Brain MRIs with pseudo-continuous arterial spin labeling (pCASL) measured CBF.
  • Participants were categorized into three eGFR stages based on creatinine levels.

Main Results:

  • Significantly higher CBF was observed in participants with high and moderate eGFR compared to those with low eGFR.
  • CBF was notably higher in the hippocampus and parahippocampal gyrus in higher eGFR groups.
  • A positive correlation was found between CBF and eGFR, and a negative correlation between CBF and creatinine levels.

Conclusions:

  • CBF levels differ significantly across eGFR stages, indicating its sensitivity to renal function changes.
  • CBF shows potential as an early biomarker for monitoring cerebral perfusion changes linked to kidney health.
  • The study highlights the link between renal and brain health, with CBF reflecting early cerebral changes.