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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

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Biomarkers.

Min Chu1, Liyong Wu1, Pedro Rosa-Neto2,3,4,5

  • 1Xuanwu Hospital, Capital Medical University, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Glymphatic dysfunction and inflammation are linked in Alzheimer's disease (AD). Lower glymphatic function (DTI-ALPS) correlated with increased inflammation markers (GFAP), impacting tau pathology.

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Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Research

Background:

  • Alzheimer's Disease (AD) involves protein deposition, with growing evidence for glymphatic dysfunction and neuroinflammation roles.
  • The direct interplay between glymphatic function and inflammation in AD pathogenesis remains under-investigated.

Purpose of the Study:

  • To investigate the relationship between glymphatic system function and inflammatory markers in individuals with cognitive impairment.
  • To explore how glymphatic dysfunction and neuroinflammation interact to influence AD pathology, specifically tau aggregation.

Main Methods:

  • A cohort of individuals with cognitive impairment (including AD and MCI) and cognitively normal controls was studied.
  • Glymphatic function was assessed using Diffusion Tensor Imaging - Analysis of Longitudinal Polarization Transfer (DTI-ALPS).
  • Inflammation was evaluated via plasma GFAP, sTREM2, and cerebrospinal fluid (CSF) neuroinflammation markers.

Main Results:

  • Lower DTI-ALPS scores were associated with distinct plasma GFAP and CSF inflammation profiles.
  • A significant negative correlation was observed between DTI-ALPS and plasma GFAP levels.
  • Glymphatic function and astrocyte reactivity were found to synergistically increase tau load.

Conclusions:

  • Findings indicate a significant link between glymphatic dysfunction and inflammation in Alzheimer's Disease.
  • These results suggest potential therapeutic strategies targeting both glymphatic and inflammatory pathways for AD treatment.