Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolomic Profiles in Down Syndrome: A Scoping Review of Convergent and Context-Dependent Patterns.

Journal of intellectual disability research : JIDR·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico.

eLife·2023
Same author

Corrigendum to "Best match graphs".

Journal of mathematical biology·2021
Same author

Bacterial Diversity and Interaction Networks of <i>Agave lechuguilla</i> Rhizosphere Differ Significantly From Bulk Soil in the Oligotrophic Basin of Cuatro Cienegas.

Frontiers in plant science·2020
Same author

From pairs of most similar sequences to phylogenetic best matches.

Algorithms for molecular biology : AMB·2020

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Ángel Radamés Rábago Monzón1, Juan Fidel Osuna Ramos1, Yair Cruz Narvaez2

  • 1Universidad Autónoma de Sinaloa, Culiacán, SI, Mexico.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals distinct gut microbiota and metabolic profiles associated with Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD). These findings pave the way for personalized interventions targeting gut health to improve cognitive function and patient outcomes.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Microbiome research
  • Metabolomics
  • Neurodegenerative disease mechanisms

Background:

  • Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD) are significant public health issues.
  • Gut microbiota alterations are increasingly implicated in the pathogenesis of both T2DM and AD.
  • Metagenomic and metabolomic analyses offer insights into the gut microbiome's role in metabolic regulation and dementia risk.

Purpose of the Study:

  • To investigate the distinct gut microbiota and metabolic profiles in individuals with T2DM and AD.
  • To explore the relationship between gut dysbiosis, metabolic changes, and cognitive decline.
  • To identify potential biomarkers for early diagnosis and targets for personalized therapeutic strategies.

Main Methods:

  • A cross-sectional, observational, comparative study involving four groups: Control, T2DM, AD, and AD with T2DM.
  • Quantitative analysis of gut microbiome diversity and function using bioinformatics tools (MetaHit).
  • Metabolomic profiling of urine and stool samples using Magnetic Resonance Mass Spectrometry (MRMS) and RStudio for analysis.

Main Results:

  • Distinct patterns of intestinal dysbiosis and metabolic alterations were observed in T2DM and AD patients, varying by age.
  • Significant correlations were identified between microbiological, metabolomic, and clinical biomarkers, particularly those linked to cognitive decline.
  • Specific fecal and urinary metabolites were found to be associated with disease states, including (+/-)-Ethylketocyclazocine, (-)-Quebrachamine, (-)-jasmonoyl-L-isoleucine, (Phenylthio) acetic acid, and 2,3-Diketo-L-gulonate.

Conclusions:

  • The study establishes a link between specific gut microbiota and metabolic signatures and cognitive decline in T2DM and AD.
  • Findings provide insights into the underlying disease mechanisms involving gut dysbiosis.
  • Results support the development of personalized interventions modulating microbiota and metabolomic profiles to mitigate cognitive impairment.