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Related Concept Videos

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Meghan K Ramirez1, Connor J Phipps1, Abi Heller1

  • 1University of Nebraska Medical Center, Omaha, NE, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Early life physical and financial well-being are linked to the hippocampus

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neuroscience

Background:

  • Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss.
  • The hippocampus, particularly the CA1 subfield, is vulnerable to AD-related atrophy.
  • Early-life factors may influence long-term AD risk by affecting hippocampal development during sensitive periods like periadolescence.

Purpose of the Study:

  • To investigate the relationship between early-life well-being and hippocampal structure in children.
  • To examine the role of the CA1 subfield in relational memory during childhood.
  • To explore how physical and financial well-being in childhood may predict AD vulnerability later in life.

Main Methods:

  • Utilized data from the Polygenic Risk of Alzheimer's disease in Nebraska Kids (PRANK) study.
  • Collected fMRI-BOLD data during a relational memory task in children aged 8-13 years.
  • Measured hippocampal subfield volumes, including CA1, using Automatic Segmentation of Hippocampal Subfields (ASHS) software.

Main Results:

  • Successful relational subsequent memory (RSM) was associated with increased activity in the right anterior CA1.
  • Right CA1 volume positively correlated with RSM performance.
  • Lower physical and financial well-being were negatively associated with CA1 volumes in both hemispheres.

Conclusions:

  • The CA1 subfield plays a crucial role in successful relational memory performance in children.
  • Early-life physical and financial well-being are associated with the volume of the AD-vulnerable CA1 subfield.
  • These findings highlight the potential impact of periadolescent development on late-life AD risk.