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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Kittithatch Booncharoen1,2,3, Poosanu Thanapornsangsuth4,5,6, Watayuth Luechaipanit7

  • 1Neurology Center, Phyathai 1 Hospital, Bangkok, Rachathewi, Thailand.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Combining FDG-PET patterns with plasma p-tau217 significantly improves diagnostic specificity for Alzheimer's disease (AD) pathology. This integration enhances the accuracy of detecting beta-amyloid and tau biomarkers in patients with cognitive impairment.

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Area of Science:

  • Neurology
  • Radiology
  • Biomarker Discovery

Background:

  • FDG-PET is a long-established imaging technique for assessing hypometabolism in Alzheimer's disease (AD).
  • This study compares biomarker profiles in patients with AD versus non-AD FDG-PET patterns.
  • It explores the added diagnostic value of FDG-PET patterns alongside plasma p-tau217 for detecting amyloid-beta (Aβ) and tau pathologies.

Purpose of the Study:

  • To investigate differences in biomarker profiles based on FDG-PET patterns in mild cognitive impairment and dementia.
  • To evaluate the complementary role of AD FDG-PET patterns with plasma p-tau217 in diagnosing Aβ and tau pathology.
  • To determine the diagnostic performance of combined imaging and fluid biomarkers.

Main Methods:

  • 51 participants with mild cognitive impairment or dementia were classified by FDG-PET patterns (AD vs. non-AD).
  • Aβ-PET, tau-PET, and plasma biomarkers (p-tau217, p-tau181, GFAP, NfL) were measured.
  • ROC analyses determined optimal cut-off values for p-tau217 and assessed diagnostic performance with FDG-PET patterns.

Main Results:

  • AD FDG-PET patterns showed significantly higher rates of Aβ positivity (A+) and Aβ/tau positivity (A+T+) compared to non-AD patterns.
  • Elevated Aβ-PET centiloid, tau SUVR, and plasma biomarkers including p-tau217 were observed in the AD pattern group.
  • Plasma p-tau217 alone demonstrated excellent diagnostic performance, and combining it with FDG-PET patterns enhanced specificity for A+T+ detection.

Conclusions:

  • FDG-PET patterns, especially when combined with plasma p-tau217, enhance diagnostic specificity for A+ and A+T+ pathology.
  • Integrating imaging (FDG-PET) and fluid (p-tau217) biomarkers offers complementary value for accurate AD diagnosis.
  • These findings support a multimodal approach for improved Alzheimer's disease diagnostics.