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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Karen Blackmon1,2,3, Benard Alaka3, Catherine Bikeri Onyancha3

  • 1Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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Summary
This summary is machine-generated.

This study shows a digital platform using wearable devices and smartphones effectively tracks vitality in older Kenyan adults. The Vitality Index (VI) demonstrated high adherence and reliability, proving feasible for healthy aging research.

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Area of Science:

  • Gerontology
  • Digital Health
  • Psychometrics

Background:

  • Vitality is crucial for healthy aging but difficult to define and measure.
  • Dynamic fluctuations in vitality, missed by static measures, may predict frailty.
  • A passive sensing and active probing digital platform was developed for high-density vitality capture.

Purpose of the Study:

  • To develop and evaluate a digital platform for dynamic vitality assessment in older adults.
  • To assess the feasibility and psychometric properties of a novel Vitality Index (VI).
  • To explore the potential for tracking accelerated aging dynamics in Kenyan adults.

Main Methods:

  • A 12-month study involving 79 cognitively unimpaired Kenyan adults (≥35 years).
  • Participants used Fitbit Inspire 3 for passive sensing (heart rate, sleep, activity).
  • A weekly 10-item Vitality Index (VI) and spatial working memory task were administered via mobile app.

Main Results:

  • High adherence observed: 97% device wear, 85% VI completion, 96% task completion.
  • The VI demonstrated good internal consistency (α=0.75) and test-retest reliability (r=0.73).
  • VI correlated negatively with depression (r=-0.34) and anxiety (r=-0.37), and positively with flourishing (r=0.27).

Conclusions:

  • The vitality tracking platform is feasible in older Kenyan adults, showing high compliance and sound psychometrics.
  • This paradigm provides essential data for future research on biopsychosocial risk factors for vitality loss.
  • Findings support interventional studies targeting behavioral and pharmaceutical approaches to enhance vitality.