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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jennifer Monereo-Sánchez1, Catarina Tristão-Pereira1, Valentin Fuster2,3

  • 1Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

The PESA-Brain study investigates how cardiovascular disease risk factors, like atherosclerosis, impact early Alzheimer's disease brain changes in middle-aged adults. Findings aim to identify modifiable factors for dementia prevention.

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Area of Science:

  • Neuroscience
  • Cardiology
  • Public Health

Background:

  • Alzheimer's disease (AD) and cardiovascular disease (CVD) share risk factors, but the link between atherosclerosis and early brain changes is unclear.
  • The PESA-Brain study examines cardiovascular burden, cerebrovascular health, and AD pathology markers in asymptomatic middle-aged individuals.

Purpose of the Study:

  • To explore the relationship between cardiovascular disease and early brain alterations.
  • To identify modifiable risk factors for Alzheimer's disease prevention in midlife.

Main Methods:

  • Longitudinal study of 1,000 participants aged 50-55 from the PESA cohort.
  • Integration of extensive cardiovascular and biomarker data with multimodal brain imaging.
  • Focus on evaluating pathways linking vascular and neurodegenerative processes.

Main Results:

  • Subclinical atherosclerosis may drive early AD-related brain alterations via impaired cerebral perfusion and neurovascular dysfunction.
  • Identification of potential mechanisms linking vascular health to neurodegeneration.

Conclusions:

  • PESA-Brain provides insights into early interactions between cardiovascular health and brain integrity.
  • Findings are crucial for understanding vascular factors in neurodegeneration and dementia development.
  • The study contributes to global efforts to combat Alzheimer's disease.