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Basic Science and Pathogenesis.

Daita Kaneda1, Norihiro Ogawa1, Takeshi Kanesaka1

  • 1Institute of Neuropathology, Fukushimura Hospital, Toyohashi, Japan.

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The Fukushimura BrainBank stores over 864 frozen brains and retinal tissues for research, aiding the study of geriatric conditions in nursing home residents. This resource supports cliniconeuropathological correlation for various age-related diseases.

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Area of Science:

  • Neuropathology
  • Geriatric Medicine
  • Neuroimaging

Background:

  • Fukushimura BrainBank (FBB) established in 1990 in Toyohashi, Japan, is a unique facility within a welfare village managing approximately 800 elderly residents.
  • The FBB is integrated with Fukushimura Hospital, serving as a central hub for nursing home facilities and conducting neuropathological investigations since its inception.
  • The research institute received approval in 2004 for governmental grants, supporting its research endeavors.

Purpose of the Study:

  • To establish and maintain a comprehensive biobank of brain and retinal tissues from nursing home residents.
  • To facilitate cliniconeuropathological correlation studies in geriatric conditions.
  • To support collaborative research on age-related neurological diseases.

Main Methods:

  • Collection of detailed clinical data, including behavioral and psychological symptoms, from medical records and nursing homes.
  • Acquisition of serial neuroimaging data, such as MPRAGE T1 and diffusion tensor imaging (DTI) using 1.5T MRI.
  • Neuropathological analysis of brain specimens using antibodies for beta-amyloid, tau, alpha-synuclein, and TDP-43, along with modified gallyas-silver staining.

Main Results:

  • As of end 2024, FBB stores 864 frozen brains with detailed medical records, alongside 68 brains with DTI scans.
  • 158 consents for retinal donation have been obtained, establishing a significant Asian post-mortem retinal tissue bank.
  • FBB actively collaborates with over 20 partners and supplies samples to more than 30 research institutes in Japan.

Conclusions:

  • The Fukushimura BrainBank is a valuable resource for understanding cliniconeuropathological correlations in elderly individuals residing in nursing homes.
  • The bank's extensive sample collection and ongoing research contribute significantly to the study of various geriatric conditions.
  • Continued efforts in biobanking and neuropathological analysis are crucial for advancing research in age-related neurological diseases.