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Related Concept Videos

Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

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Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
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Size-Exclusion Chromatography01:08

Size-Exclusion Chromatography

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In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...
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Ion Exchange01:17

Ion Exchange

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Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
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Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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Atomic Emission Spectroscopy: Instrumentation01:22

Atomic Emission Spectroscopy: Instrumentation

1.1K
The instrumentation of atomic emission spectrometry (AES) involves various components, including atomization devices that convert samples into gas-phase atoms and ions. There are two main types of atomization devices: continuous and discrete atomizers.  Continuous atomizers, like plasmas and flames, introduce samples in a constant stream, while discrete atomizers inject individual samples using syringes or autosamplers. The most common discrete atomizer is the electrothermal atomizer.
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Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

1.0K
Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
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Related Experiment Video

Updated: Jan 7, 2026

Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization
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A compact E x B filter isotope separation system.

Ka-Ngo Leung1, Nozomi Tanaka2

  • 1Nuclear Engineering Department, University of California, Berkeley, CA, 94720, USA.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|December 24, 2025
PubMed
Summary

A new radiofrequency-driven ion source and E x B filter efficiently separates isotopes like Boron-10 and Molybdenum-100. This technology is valuable for nuclear science, neutron production, and medical radioisotope manufacturing.

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Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization
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Area of Science:

  • Nuclear Physics
  • Plasma Physics
  • Isotope Separation

Background:

  • Efficient isotope separation is crucial for nuclear science, neutron production, and medical applications.
  • Existing methods may lack the required efficiency or specificity for certain isotopes.

Purpose of the Study:

  • To describe the design of a compact radiofrequency (RF)-driven ion source coupled with an E x B (Wien) filter.
  • To demonstrate the capability of this system for efficient isotope separation.

Main Methods:

  • Utilized computational modeling to optimize the E x B filter design.
  • Integrated an RF-driven ion source with the optimized E x B separator.

Main Results:

  • The optimized E x B filter demonstrated the potential for high enrichment of isotopes including 10B, 50Ti, 64Zn, 67Zn, 98Mo, and 100Mo.
  • The system is capable of collecting single or multiple isotopes in a single run.

Conclusions:

  • The combined RF-driven ion source and E x B filter offer an efficient solution for isotope separation.
  • This technology supports advancements in nuclear science, neutron generation, and the production of medical radioisotopes for diagnostics and therapeutics.