Related Experiment Video
Updated: Jan 7, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
The health effects of vaping and e-cigarettes: consensus recommendations
Erika Kouzoukas1, Carolina Navas1, Laurie Zawertailo2
1INTREPID Lab, Addictions Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Objective:
To develop evidence-informed recommendations on the health effects of e-cigarettes to guide healthcare practitioners and the public to balance individual and population harm reduction.
Methods:
Systematic and umbrella reviews investigating the health effects of e-cigarette use were conducted (September 2017 - January 2024). An international panel of subject matter experts (n = 23) and people in Canada with lived experience (n = 7) participated in a two-day, hybrid meeting, and used a consensus-based approach to develop recommendations. A guidance resource and four accompanying knowledge products were tested for usability with end users.
Results:
Consensus was reached on 14 recommendations spanning four health effects: carcinogen exposure, cardiovascular health, respiratory health, and nicotine dependence. Quality of evidence was voted as ranging from high/moderate to moderate/low, and strength of most recommendations was voted as strong.
Conclusions:
Guidance has been informed by best available evidence and expertise, providing direction to support decision-making. The use of established methods to evaluate divergent published literature combined with consensus-building methods among a range of stakeholders on vaping is possible. As higher quality evidence continues to emerge, recommendations will require iterative refinement.
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