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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jan Muntel1,2, Aida Kamalian3, Polina Shichkova1

  • 1Biognosys AG, Schlieren, Zurich, Switzerland.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

This study identifies novel plasma biomarkers for early Alzheimer's disease detection, preceding cognitive decline and amyloid conversion. These findings offer a less invasive alternative to current diagnostic methods.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Biomarker Discovery

Background:

  • Aging is the primary risk factor for Alzheimer's disease (AD), but the transition from healthy to pathological aging is unclear.
  • Early detection of AD is crucial, necessitating biomarkers detectable before cognitive symptoms or amyloid conversion.
  • Plasma is an ideal matrix for biomarker discovery due to its accessibility and non-invasive nature.

Purpose of the Study:

  • To develop a novel mass spectrometry (MS)-based proteomics workflow for unbiased biomarker discovery in plasma.
  • To identify early molecular changes associated with cognitive decline and Alzheimer's disease progression.
  • To discover plasma-based biomarkers that precede amyloid conversion and clinical symptoms.

Main Methods:

  • Selected participants from the BIOCARD cohort, classifying 55 as amyloid converters and 55 as matched non-converters based on CSF Aβ42/Aβ40 ratios over 10 years.
  • Analyzed 578 plasma samples using a novel MS-based proteomics workflow (Biognosys P2) involving pre-treatment, digestion, and quantitative mass spectrometry.
  • Collected longitudinal data including cognitive assessments, clinical biomarkers, and MRI scans.

Main Results:

  • Mass spectrometry revealed protein and peptide changes linked to cognitive decline and the transition to mild cognitive impairment (MCI).
  • Identified key biological pathways including lipid metabolism, extracellular matrix remodeling, axonogenesis, and synaptic activity.
  • Discovered plasma-based signatures that precede amyloid conversion and cognitive decline, detectable before clinical conversion.

Conclusions:

  • An integrated approach links molecular changes to clinical phenotypes in AD.
  • Plasma-derived biomarkers offer a less invasive alternative to cerebrospinal fluid (CSF) collection for AD diagnosis.
  • This study highlights the potential of plasma proteomics for early AD detection and understanding disease mechanisms.