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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Keith A Johnson1

  • 1Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Tau PET imaging reveals individual differences in Alzheimer's disease (AD) tau progression. A specific tau PET threshold indicates significant tau spread, informing clinical trial enrollment for AD.

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Area of Science:

  • Neuroimaging
  • Alzheimer's Disease Research
  • Biomarker Discovery

Background:

  • Tau PET imaging tracks Alzheimer's disease (AD) tauopathy progression over time.
  • Tau deposition begins in the medial temporal lobe and spreads to the neocortex with increasing amyloid-β (Aβ) burden, correlating with cognitive decline.
  • Individual variability exists in tau PET signal intensity and spread, even with similar amyloid levels.

Purpose of the Study:

  • To characterize heterogeneity in pre-clinical Alzheimer's disease tau progression using longitudinal data.
  • To identify thresholds for significant tau spread in individuals with amyloid pathology.

Main Methods:

  • Analysis of two longitudinal studies: Harvard Aging Brain Study (HABS) and A4 study.
  • Characterization of tau PET signal intensity and anatomic location in relation to amyloid-β (Aβ) burden.
  • Assessment of tau PET signal changes over a mean follow-up duration of 3.3 years.

Main Results:

  • In individuals with Aβ >24CL (N=229), those with tau > 1.2 SUVr (N=112, 49%) showed increasing tau deposition.
  • Below the tau threshold of 1.2 SUVr, no significant spread of tau PET signal to neocortical regions was observed during follow-up (slope ~0).

Conclusions:

  • The identified tau PET threshold may help stratify individuals based on their AD tau progression trajectory.
  • These findings can inform clinical trial enrollment strategies for Alzheimer's disease research.