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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anisa Dhana1, Charles Decarli2, Klodian Dhana1

  • 1Rush University Medical Center, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Impaired kidney function is linked to higher levels of neurodegeneration biomarkers like neurofilament light (NfL), total tau (t-tau), and glial fibrillary acidic protein (GFAP). Kidney function did not affect cognitive decline rates but influences biomarker measurements.

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Area of Science:

  • Neurology
  • Nephrology
  • Biomarker Research

Background:

  • Neurodegeneration biomarkers (NfL, t-tau, GFAP) are linked to cognitive decline and Alzheimer's disease risk.
  • Serum levels of these biomarkers may be elevated in individuals with reduced kidney function, irrespective of cognitive status.

Purpose of the Study:

  • To examine the association between kidney function and serum neurodegeneration biomarkers.
  • To determine if kidney impairment influences the relationship between NfL, GFAP, and t-tau and longitudinal cognitive changes.

Main Methods:

  • Analysis of 1207 older adults from the Chicago Health and Aging Project.
  • Kidney function assessed by estimated glomerular filtration rate (eGFRcr); categorized as normal, impaired, or severe.
  • Serum biomarkers measured using a bead-based immunoassay; global cognition assessed via cognitive tests.

Main Results:

  • Lower eGFRcr correlated with higher serum levels of NfL, GFAP, and t-tau.
  • Individuals with impaired and severe kidney function exhibited significantly higher NfL levels compared to those with normal function.
  • Kidney function did not modify the association between these biomarkers and cognitive decline rates.

Conclusions:

  • Impaired kidney function can influence serum levels of neurodegeneration biomarkers.
  • Estimated glomerular filtration rate (eGFRcr) should be considered in research and clinical use of NfL, GFAP, and t-tau.