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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Carling G Robinson1, Alexa Pichet Binette2,3,4, Kanta Horie1,5,6

  • 1Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Sex does not influence the link between tau Positron Emission Tomography (PET) and cerebrospinal fluid (CSF) MTBR-tau243 biomarkers. These findings suggest observed sex differences in tau-PET reflect genuine biological factors, not methodological artifacts.

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Area of Science:

  • Neuroimaging
  • Biomarkers
  • Alzheimer's Disease Research

Background:

  • Previous studies show sex differences in tau Positron Emission Tomography (PET) binding, particularly in females with Alzheimer disease (AD) biomarkers.
  • The contribution of PET methodology versus biological mechanisms to these sex differences in tau-PET remains unclear.
  • Microtubule binding region tau species (MTBR-tau243) in cerebrospinal fluid (CSF) is an established AD tau pathology biomarker, but its relation to sex differences in tau-PET is unexplored.

Purpose of the Study:

  • To investigate the relationship between CSF MTBR-tau243 and tau-PET across sexes.
  • To determine if sex moderates the association between CSF MTBR-tau243 and tau-PET.
  • To explore these relationships in individuals with and without amyloid-beta (Aβ) positivity.

Main Methods:

  • Cross-sectional analysis of CSF MTBR-tau243 and tau-PET data from two cohorts (Swedish BioFINDER-2 and Knight-ADRC).
  • Tau-PET imaging utilized Flortaucipir (Knight-ADRC) and RO948 (BioFINDER-2) tracers.
  • Statistical analysis focused on the interaction between sex and CSF MTBR-tau243 in predicting temporal tau-PET, including analyses stratified by Aβ status.

Main Results:

  • Significant associations were found between CSF MTBR-tau243 and temporal tau-PET in both cohorts.
  • No significant interaction between sex and CSF MTBR-tau243 was observed in predicting temporal tau-PET in either cohort.
  • These findings remained consistent within the amyloid-beta (Aβ)-positive subgroups.

Conclusions:

  • Sex does not moderate the relationship between tau-PET and CSF MTBR-tau243, indicating these are distinct markers of aggregated tau pathology.
  • The observed sex differences in tau-PET are likely attributable to genuine biological factors rather than PET methodological influences.
  • This study clarifies the interpretation of sex-specific findings in tau-PET imaging for Alzheimer disease research.