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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jie Wang1, Xiaoxi Ma1, Jiaying Lu2

  • 1Institute and department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary

The Shanghai Memory Study (SMS) established a comprehensive cohort for neurodegenerative cognitive disorders. Biomarker analysis in SMS predicts Alzheimer's disease progression, aiding in understanding disease mechanisms.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomarker Research

Background:

  • Advancements in neurodegenerative disorder biomarkers and therapies exist.
  • China lacks integrated clinical cohorts for memory clinic patients with multi-modal biomarker assessments.

Purpose of the Study:

  • To establish the Shanghai Memory Study (SMS), a prospective hospital-based cohort.
  • To integrate comprehensive clinical assessments with multi-modal biomarker examinations.
  • To facilitate exploration of Alzheimer's disease pathogenesis and cognitive disorder understanding.

Main Methods:

  • Recruited 2,001 participants with cognitive complaints.
  • Utilized extensive clinical, neuropsychological, genotyping, MRI, PET, and biospecimen collection.
  • Performed plasma biomarker assays (Simoa platform) and molecular neuroimaging (Aβ PET, tau PET).

Main Results:

  • Identified varying proportions of amyloid-beta and tau positivity across Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia groups.
  • Observed trends in plasma biomarkers (Aβ40, Aβ42, t-tau, NfL, p-tau181) correlating with cognitive decline (CDR score).
  • Found that low Aβ42/Aβ40 and high p-tau181 at baseline predicted higher Alzheimer's disease risk in aMCI patients.

Conclusions:

  • The SMS provides an integrated framework for cognitive disorder research.
  • SMS will advance the understanding of Alzheimer's disease pathogenesis.
  • SMS deepens insights into the mechanisms of cognitive disorders.