Related Experiment Video
Updated: Jan 7, 2026

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Ent-abietane diterpenoids with α-glucosidase inhibitory activity from Phlogacanthus curviflorus
Qian Wu1, Ren-Fen Ma1, Hua Zhang1
1School of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Abstract:
Fourteen previously unreported ent-abietane diterpenoids, named curviflorinoids A-N, comprising six intact, six mononor, and two trinor derivatives, were isolated from the twigs and leaves of Phlogacanthus curviflorus. Their structures with absolute configurations were established by spectroscopic means, comprising HR-ESIMS, NMR, ECD and single crystal X-ray crystallography. All of them except curviflorinoid N were evaluated for their inhibitory activity against the diabetic target α-glucosidase. Curviflorinoid D exhibited the most potent inhibition, with an IC50 value of 2.70 μM. The binding mode of curviflorinoid D to α-glucosidase was further investigated, which identified it as a mixed-type inhibitor.
More Related Videos
09:21Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
09:57Separation of Bioactive Small Molecules, Peptides from Natural Sources and Proteins from Microbes by Preparative Isoelectric Focusing IEF Method
Published on: June 14, 2020
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Dipeptidyl Peptidase 4 Inhibitors