Left Atrial function in Pediatric Cardiomyopathies: A Multi-Center Study
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Left atrial reservoir strain (LAS) is a valuable predictor of adverse outcomes in pediatric cardiomyopathy patients, offering insights beyond traditional echocardiographic measures for improved risk stratification.
Area Of Science
- Cardiology
- Pediatric Cardiology
- Echocardiography
Background
- Left ventricular systolic dysfunction is linked to poor outcomes in pediatric cardiomyopathies.
- The prognostic role of diastolic function, specifically left atrial function, remains underexplored in this population.
Purpose Of The Study
- To assess the association between left atrial (LA) function, measured by 2D-speckle tracking echocardiography (2D-STE), and adverse outcomes in pediatric cardiomyopathy patients.
- To determine if LA function provides incremental prognostic information compared to conventional echocardiographic parameters.
Main Methods
- Retrospective analysis of 138 pediatric cardiomyopathy patients and 45 controls.
- Measurement of LA reservoir strain (LAS) and other echocardiographic parameters (GLS, LVEF, LAVi, E/e') from baseline echocardiograms.
- Composite endpoint: cardiovascular death, aborted death, VAD implantation, or cardiac transplantation, analyzed using Cox models and ROC curves.
Main Results
- Lower LAS was significantly associated with adverse outcomes (p<0.001).
- LAS independently predicted adverse outcomes in multivariable analyses, outperforming LA volume index (LAVi).
- LAS demonstrated an Area Under the Curve (AUC) of 0.739 for outcome prediction.
Conclusions
- Left atrial reservoir strain (LAS) is independently associated with adverse outcomes in pediatric cardiomyopathy.
- LAS provides incremental prognostic value beyond conventional echocardiographic measures.
- Routine incorporation of LAS may enhance risk stratification and guide early interventions in pediatric cardiomyopathy.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...