Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

360
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
360
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

189
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
189

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcatheter correction of superior sinus venosus atrial septal defect: single centre experience with short- to medium-term outcomes.

Cardiology in the young·2026
Same author

Effects of under- and overexpansion on performance of Edwards SAPIEN 3 and MyVal OCTACOR transcatheter heart valves.

Cardiology in the young·2026
Same author

Generalized Arterial Calcification of Infancy (GACI): State of the Art and Clinical Perspectives.

Journal of cardiovascular development and disease·2026
Same author

Reduced myocardial work in Fontan circulation: feasibility, reproducibility, and diagnostic performance.

European heart journal. Imaging methods and practice·2026
Same author

Anomalous Coronary Artery Origin from Pulmonary Artery and Coronary Fistulas: A Review About Coronary Steal Phenomenon.

Children (Basel, Switzerland)·2026
Same author

Not just palliation: integrating patent ductus arteriosus and right ventricular outflow tract stenting into modern surgical pathways for tetralogy of Fallot.

Cardiology in the young·2026

Related Experiment Video

Updated: Jan 7, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.0K

Left Atrial Function in Pediatric Cardiomyopathies: A Multicenter Study.

Jolanda Sabatino1, Martina Avesani2, Sara Moscatelli3

  • 1Pediatric and Congenital Cardiology Unit, Department for Women's and Children's Health, University Hospital of Padova, Padova, Italy; Pediatric Research Institute (IRP) "Città della Speranza", Padua, Italy; Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|December 24, 2025
PubMed
Summary

Left atrial reservoir strain (LAS) is a valuable predictor of adverse outcomes in pediatric cardiomyopathy patients, offering insights beyond traditional echocardiographic measures for improved risk stratification.

Keywords:
Atrial functionPediatric cardiomyopathiesSpeckle tracking

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.2K
Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

10.4K

Related Experiment Videos

Last Updated: Jan 7, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.0K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.2K
Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

10.4K

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Echocardiography

Background:

  • Left ventricular systolic dysfunction is linked to poor outcomes in pediatric cardiomyopathies.
  • The prognostic role of diastolic function, specifically left atrial function, remains underexplored in this population.

Purpose of the Study:

  • To assess the association between left atrial (LA) function, measured by 2D-speckle tracking echocardiography (2D-STE), and adverse outcomes in pediatric cardiomyopathy patients.
  • To determine if LA function provides incremental prognostic information compared to conventional echocardiographic parameters.

Main Methods:

  • Retrospective analysis of 138 pediatric cardiomyopathy patients and 45 controls.
  • Measurement of LA reservoir strain (LAS) and other echocardiographic parameters (GLS, LVEF, LAVi, E/e') from baseline echocardiograms.
  • Composite endpoint: cardiovascular death, aborted death, VAD implantation, or cardiac transplantation, analyzed using Cox models and ROC curves.

Main Results:

  • Lower LAS was significantly associated with adverse outcomes (p<0.001).
  • LAS independently predicted adverse outcomes in multivariable analyses, outperforming LA volume index (LAVi).
  • LAS demonstrated an Area Under the Curve (AUC) of 0.739 for outcome prediction.

Conclusions:

  • Left atrial reservoir strain (LAS) is independently associated with adverse outcomes in pediatric cardiomyopathy.
  • LAS provides incremental prognostic value beyond conventional echocardiographic measures.
  • Routine incorporation of LAS may enhance risk stratification and guide early interventions in pediatric cardiomyopathy.