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Clinical Manifestations.

Darren M Lipnicki1, Ashleigh S Vella1, Erico Costa2

  • 1Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Disturbing dreams predict dementia and Alzheimer's disease (AD) in younger adults aged 60-69. These dreams may signal early-stage neurodegeneration, particularly in men.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Sleep Medicine

Background:

  • Previous research linked distressing dreams to future dementia in older white Americans.
  • The current study expanded this by examining disturbing dreams (nightmares, bad dreams) and their association with Alzheimer's disease (AD) and all-cause dementia.
  • The investigation included a broader age range (60-89 years) and diverse international populations.

Purpose of the Study:

  • To investigate if disturbing dreams predict incident all-cause dementia and AD.
  • To assess these predictions across different age groups (60-69, 70-79, 80-89 years) and sexes.
  • To explore the potential of disturbing dreams as a pre-clinical indicator for dementia and AD.

Main Methods:

  • Utilized data from six longitudinal cohort studies across Brazil, China, France, Italy, South Korea, and Taiwan, involving 8339 participants without baseline dementia or Parkinson's disease.
  • Harmonized disturbing dream data (yes/no, weekly frequency) and employed Cox regressions with random effects for study, stratifying by sex and age.
  • Adjusted for 21 covariates, including sleep issues, medications, depression, and APOE*4, with additional analyses including anxiety.

Main Results:

  • Overall, disturbing dreams did not predict dementia or AD in all age groups or sexes.
  • However, disturbing dreams predicted AD in men (OR=2.03-4.00) and dementia (OR=1.89-3.93) and AD (OR=4.96) in individuals aged 60-69 years.
  • Weekly disturbing dreams (<1/week or ≥1/week) significantly predicted dementia and AD across multiple analyses, especially in the 60-69 age group.

Conclusions:

  • Disturbing dreams are significant predictors of incident dementia and AD in individuals aged 60-69 years.
  • Disturbing dreams also predict incident AD in men aged 60-89 years.
  • These findings suggest that disturbing dreams may serve as an early pre-clinical indicator or prodrome for dementia and AD.