Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease-associated RNA and protein signatures in iPSC-derived microglia model of Alzheimer's disease.

Frontiers in neuroscience·2026
Same author

Variant-Specific tRNA-Derived Fragments Induced By Severe Acute Respiratory Syndrome Coronavirus 2: Implications for Disease Outcome Differentiation.

Journal of medical virology·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Clinical Outcome Prediction by High-Resolution Computed Tomography and Echocardiography Assessment of Pulmonary Hypertension in Patients with Bronchiectasis.

Tuberculosis and respiratory diseases·2025
Same author

Metastatic melanoma presenting with gastrointestinal bleeding and a gastric mass.

Gastroenterology report·2025
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Meher Garg1,2, Inhan Lee3

  • 1SIU School of Medicine, Physican pipeline program, Springfield, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) is linked to impaired gastric acid secretion and autonomic pathways, potentially explaining gastrointestinal issues in patients. This study reveals significant pathway downregulation in AD, highlighting a broader autonomic dysfunction.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Genetics

Background:

  • Alzheimer's Disease (AD) is a progressive neurodegenerative disorder.
  • Autonomic dysfunction, particularly gastrointestinal (GI) issues like impaired gastric acid secretion and motility, is increasingly recognized in AD patients.
  • The molecular mechanisms underlying AD-associated GI dysregulation are not well understood.

Purpose of the Study:

  • To investigate molecular pathways associated with gastric acid secretion in Alzheimer's Disease.
  • To uncover potential links between these pathways, autonomic dysfunction, and GI symptoms in AD.

Main Methods:

  • Analysis of Gene Expression Omnibus (GEO) dataset GSE132903, comparing RNA expression in the middle temporal gyrus of 97 AD patients and 98 non-demented (ND) controls.
  • Differential expression analysis using GEO2R, followed by pathway enrichment analysis with STRING-DB.
  • Examination of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to gastric acid secretion and autonomic regulation, with functional annotations from GeneCards.

Main Results:

  • Significant downregulation of pathways involved in gastric acid secretion and autonomic regulation was observed in the AD group compared to controls.
  • The Gastric Acid Secretion pathway (hsa04971) showed a significant FDR of 0.00086.
  • Disruptions were also noted in synaptic vesicle cycling (hsa04961), salivary secretion (hsa04925), and endocrine calcium reabsorption pathways, suggesting a broader impact on autonomic functions.

Conclusions:

  • Downregulation of gastric acid secretion and related autonomic pathways in AD indicates wider autonomic dysfunction.
  • Impaired gastrointestinal and autonomic pathways likely play a role in AD pathogenesis and symptomology.
  • Further research is warranted for early detection and therapeutic strategies targeting GI symptoms in AD.