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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Avital Dell'Ariccia1, Armen Bodossian1, Logan Xin Zhang1

  • 1Quantified Imaging, London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Arterial Spin Labelling (ASL) shows promise as a non-invasive biomarker for Alzheimer's disease (AD) progression. A novel meta-region of interest (meta-ROI) derived from ASL data correlated well with cognitive scores, suggesting its utility in monitoring disease.

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Alzheimer's Disease Research

Background:

  • Arterial Spin Labelling (ASL) is a non-invasive MRI technique for measuring cerebral blood flow (CBF).
  • CBF changes are indicative of Alzheimer's disease (AD) progression and can be used as imaging biomarkers.
  • This study explores ASL as a potential alternative to invasive biomarkers like PET scans.

Purpose of the Study:

  • To introduce a novel Alzheimer's disease meta-region of interest (meta-ROI) derived from ASL data.
  • To assess the correlation between the ASL-derived meta-ROI and cognitive scores.
  • To evaluate ASL's potential for tracking disease progression across cognitively normal, MCI, and AD stages.

Main Methods:

  • ASL data from the Alzheimer's Disease Neuroimaging Initiative (ADNI3) was analyzed.
  • A meta-ROI was constructed from 17 regions showing a linear relationship with ADAS-Cog scores.
  • Pearson's correlation coefficient (R) was used to measure the association between meta-ROI CBF and ADAS-Cog scores in a test set.

Main Results:

  • A significant correlation (R=0.72) was observed between the meta-ROI scores and cognitive performance.
  • This correlation is comparable to values reported for PET (R=0.75) and CSF/plasma biomarkers.
  • The findings suggest ASL-derived perfusion is a reliable indicator of cognitive status in AD.

Conclusions:

  • The strong correlation supports the use of ASL-derived biomarkers for predicting and monitoring AD progression.
  • ASL offers a non-invasive imaging alternative for assessing disease status.
  • Further research can validate ASL's role in clinical settings for dementia management.