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Related Experiment Video

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

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Published on: June 14, 2020

Basic Science and Pathogenesis.

Moltira Promkan¹, Kewarin Jinawong¹, Rungruedee Kimseng¹

¹University of Kentucky, Lexington, KY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 24, 2025

Summary

This summary is machine-generated.

Aging and Alzheimer's disease genetic predisposition worsen brain blood vessel structure and function. This study reveals significant cerebrovascular degeneration and dysfunction, offering insights for neurodegenerative disease research.

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Area of Science:

Neuroscience
Vascular Biology
Gerontology

Background:

Cerebrovascular pathology frequently co-occurs with Alzheimer's disease (AD) clinical signs.
These pathologies may accelerate AD progression and reduce treatment effectiveness.
The impact of aging and AD genetic predisposition on cerebrovascular health remains understudied.

Purpose of the Study:

To investigate how aging and genetic predisposition to Alzheimer's disease affect brain vascular architecture and function.
To determine if Alzheimer's-related pathologies exacerbate cerebrovascular damage.

Main Methods:

Intravital two-photon imaging in young and old wild-type and Tg2576 Alzheimer's model mice.
Assessment of vascular architecture, pathology, and function using Methoxy-X04 for amyloid plaques/CAA and rhodamine dextran for blood flow.
Neurovascular coupling measured via arteriole dilation in response to whisker stimulation.

Main Results:

Aged wild-type mice showed reduced neurovascular function; Tg2576 mice with cerebral amyloid angiopathy (CAA) exhibited more severe impairment.
Alzheimer's predisposition led to increased aneurysms and microvessel tortuosity in cortical vessels.
Reduced cerebrovascular integrity and increased astrocyte marker GFAP were observed in Tg2576 mice, mirroring human AD vascular pathology.

Conclusions:

Aging and amyloid-beta predisposition significantly contribute to cerebrovascular degeneration and dysfunction.
Findings highlight the translational relevance of observed vascular pathologies to human AD.
Developed imaging approaches can aid future research into AD pathogenesis, pathophysiology, and treatment.