Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and literature insights into the frontotemporal dementia and motor neuron disease spectrum.

Discover mental health·2026
Same author

From MRI to 3D printing: a tangible neuroeducational tool for visualizing hippocampal morphology and Alzheimer's disease progression.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Structural MRI in frontotemporal dementia and Alzheimer's disease: stage-dependent atrophy patterns.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice.

Iranian journal of psychiatry·2026
Same author

Feasibility and real-life effectiveness of a cognitive rehabilitation package(CIMORGH) on iranian illiterate older adults with mild cognitive impairment: A pilot nonrandomized clinical trial.

Applied neuropsychology. Adult·2026
Same author

Turning versus straight walking under dual-task conditions: a preliminary study for identifying mild cognitive impairment and Alzheimer's disease.

BMC neurology·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Clinical Manifestations.

Setareh Rassa1, Arman Hajikarim-Hamedani1, Nikan Shafiei Alavijeh1

  • 1Cognitive Neurology, Dementia and Neuropsychiatry Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran (Islamic Republic of).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Frontotemporal dementia (FTD) and traumatic brain injury (TBI) both cause frontal lobe dysfunction but differ significantly. FTD affects older adults with progressive decline, while TBI impacts younger individuals with acute symptoms and varied brain imaging.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • The prefrontal cortex, comprising dorsolateral and ventromedial regions, governs executive functions and emotional processing, respectively.
  • Frontal lobe syndrome results from prefrontal brain injury, with diverse causes including trauma, stroke, tumors, and neurodegenerative diseases.
  • Differentiating behavioral and cognitive symptoms is critical for diagnosing the underlying cause of frontal lobe dysfunction.

Purpose of the Study:

  • To systematically review and compare clinical and neuroimaging findings in frontotemporal dementia (FTD) and traumatic brain injury (TBI).
  • To highlight the distinct demographic profiles, symptom trajectories, and neuroimaging characteristics of FTD and TBI.
  • To emphasize the importance of these distinctions for accurate diagnosis and targeted treatment strategies.

Main Methods:

  • A systematic literature review was conducted following PRISMA guidelines, searching PubMed, Scopus, Web of Science, and PsycInfo (1991-2025).
  • Data extraction focused on demographics, study characteristics, population details, behavioral and cognitive symptoms, and neuroimaging findings.
  • Methodological quality was assessed using modified Cochrane and Effective Public Health Practice Project tools.

Main Results:

  • Frontotemporal dementia (FTD) predominantly affects older adults, presenting with progressive behavioral changes (disinhibition, apathy) and executive function deficits, often showing frontal/anterior temporal atrophy on neuroimaging.
  • Traumatic brain injury (TBI) typically affects younger individuals, causing acute behavioral disturbances and cognitive deficits, with variable neuroimaging findings often showing inferior medial frontal lobe damage.
  • Neuroimaging in FTD typically reveals specific patterns of brain atrophy, whereas TBI findings vary based on injury severity and location.

Conclusions:

  • FTD and TBI represent distinct etiologies of frontal lobe dysfunction, differing in patient demographics, symptom progression, and characteristic neuroimaging findings.
  • FTD is characterized by gradual decline and specific atrophy patterns, while TBI presents with more immediate symptoms and variable injury markers.
  • Accurate differentiation between FTD and TBI is essential for effective diagnosis and the implementation of tailored therapeutic interventions.