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Related Experiment Video

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Clinical Manifestations.

Nicole Grant1, Natalie A Phillips2

  • 1Concordia University, Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Hearing loss (HL) may overestimate cognitive impairment in females with mild cognitive impairment (MCI) using simple screening tests. Comprehensive assessments are crucial for accurate cognitive evaluation in older adults with HL.

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Area of Science:

  • Neuroscience
  • Audiology
  • Gerontology

Background:

  • Age-related hearing loss (HL) is linked to cognitive decline and dementia risk.
  • The influence of sex on the association between HL and cognition remains under-explored.

Purpose of the Study:

  • To investigate the relationship between hearing measures and cognitive performance in males and females with mild cognitive impairment (MCI).
  • To determine if sex moderates the association between HL and cognitive function.

Main Methods:

  • 260 older adults with MCI from the COMPASS-ND study were analyzed.
  • Participants were categorized by hearing status (normal hearing vs. HL) and sex.
  • Cognitive performance was assessed using screening (MoCA) and comprehensive neuropsychological tests (RAVLT, BVMT-R, Face-Name Association). Speech-in-noise perception was measured using the Canadian Digit Triplet Test.

Main Results:

  • Females with HL were more likely to fail the MoCA screening compared to normal hearing females (p=0.02).
  • This screening bias was not observed in males or when hearing-dependent MoCA items were removed.
  • Speech-in-noise perception correlated with MoCA, RAVLT, and BVMT-R performance in males, but not females.

Conclusions:

  • Sex influences the association between HL and cognitive performance, particularly on screening tests.
  • Simple cognitive screening may overestimate MCI in females with HL.
  • Comprehensive neuropsychological assessments are vital for accurate cognitive evaluation in older adults, especially those with hearing loss.