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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jijing Wang1,2,3, Ling Teng1,2,3, Sashini L De Tissera4

  • 1Mass General Brigham, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) molecular signatures show distinct pathways in the amygdala, unlike the neocortex. This study provides a molecular atlas for LATE-NC, aiding future research and therapies.

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Area of Science:

  • Neuroscience
  • Genomics
  • Pathology

Background:

  • Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is a major cause of dementia.
  • Molecular mechanisms underlying LATE-NC are not well understood.

Purpose of the Study:

  • To investigate the molecular alterations associated with LATE-NC in post-mortem brain tissues.
  • To identify specific gene expression patterns in the amygdala and dorsolateral prefrontal cortex (DLPFC) related to LATE-NC.

Main Methods:

  • Bulk RNA sequencing (RNA-seq) on amygdala and DLPFC tissues from 959 participants.
  • Linear regression models to associate RNA expression with LATE-NC burden, adjusting for age, sex, and ADNC.
  • Gene Ontology (GO) analysis to identify overrepresented pathways.

Main Results:

  • In the amygdala, 257 genes were positively and 178 genes negatively correlated with LATE-NC (FDR <0.05).
  • Downregulated pathways in the amygdala included synaptic transmission; upregulated pathways involved microtubule-based movement.
  • No significant gene associations were found in the DLPFC, but targeted analysis revealed 8 positively and 28 negatively associated genes.

Conclusions:

  • Distinct molecular signatures characterize LATE-NC in the amygdala, with differing patterns in the neocortex.
  • Findings emphasize the importance of brain-region-specific multi-omic studies in neurodegeneration.
  • This study provides a foundational molecular atlas of LATE-NC, supporting disease modeling and therapeutic development.