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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Rayan Mroué1, Guilherme Povala1, Bruna Bellaver1

  • 1University of Pittsburgh, Pittsburgh, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease tau pathology spreads through specific brain networks, influencing cognitive decline. Identifying these tau deposition patterns may help predict clinical outcomes.

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Alzheimer's disease (AD) is characterized by progressive tau pathology.
  • Individual differences in tau deposition patterns may lead to varied clinical presentations.
  • Understanding tau spread is crucial for diagnosing and treating AD.

Purpose of the Study:

  • To investigate distinct tau deposition patterns in the brain.
  • To link these patterns with specific cognitive profiles in individuals with and without cognitive impairment.
  • To explore the progression of tau pathology across different brain networks.

Main Methods:

  • Utilized tau PET imaging (Flortaucipir and MK6240) in 106 individuals.
  • Analyzed tau uptake in major brain networks and the entorhinal cortex.
  • Correlated tau deposition pathways with cognitive scores (MoCA, Memory, Attention, Visuospatial).

Main Results:

  • Tau pathology consistently spread from the entorhinal cortex to the limbic network.
  • Three distinct tau propagation pathways were identified, involving Visual, Default Mode, or Dorsal Attention networks.
  • Individuals with tau in the Visual network showed lower attention and visuospatial scores.

Conclusions:

  • Tau pathology follows a hierarchical progression but peaks in specific networks.
  • These distinct tau deposition pathways are associated with different clinical manifestations in Alzheimer's disease.
  • This study provides a model for understanding the link between tau spread and cognitive decline in AD.