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Published on: September 20, 2018
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Clinical Manifestations
1Danish Dementia Research Centre, Copenhagen, Copenhagen, Denmark.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Combining plasma phosphorylated tau 217 (p-tau217) with cross-cultural cognitive tests significantly improves Alzheimer's Disease (AD) diagnosis in diverse populations. This approach enhances accuracy for identifying AD in multiethnic memory clinic patients.
Area of Science:
- Neurology
- Biomarkers
- Cognitive Assessment
Background:
- Growing multiethnic populations necessitate scalable Alzheimer's Disease (AD) identification methods.
- Cross-cultural cognitive tests and plasma biomarkers are emerging tools for AD detection.
- The combined diagnostic value of these approaches remains underexplored.
Purpose of the Study:
- To evaluate the added value of plasma phosphorylated tau 217 (p-tau217) combined with cross-cultural cognitive tests.
- To assess diagnostic accuracy for clinical AD in culturally and linguistically diverse patients.
Main Methods:
- Retrospective study of 337 mixed memory clinic patients born outside their country of examination.
- Assessment using Rowland Universal Dementia Assessment Scale (RUDAS) or Multicultural Cognitive Examination (MCE).
- Plasma p-tau217 analysis and k-fold logistic regression for diagnostic accuracy.
Main Results:
- Cross-cultural tests alone showed good AD identification (AUC: 0.811-0.815).
- Adding plasma p-tau217 significantly improved diagnostic accuracy (AUC: 0.909-0.915).
- Significant diagnostic improvement was observed for both RUDAS and MCE when combined with p-tau217.
Conclusions:
- Plasma p-tau217 combined with RUDAS/MCE significantly enhances clinical AD diagnosis in diverse cohorts.
- Culturally appropriate cognitive tests are crucial for minority ethnic groups.
- Combining cognitive tests with plasma biomarkers aids AD diagnosis, warranting further research into novel blood-based markers.
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