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Updated: Jan 7, 2026

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
Published on: February 16, 2017
[Expert consensus on the application of passive immune preparation for post-exposure prophylaxis against tetanus]
Abstract:
Non-neonatal tetanus is an acute, specific and toxic disease characterized by persistent tonic contraction and paroxysmal spasms of skeletal muscles caused by Clostridium tetani invading the human body through skin or mucosal breaks, reproducing in an anaerobic environment and producing tetanospasmin. After tetanus exposure, debridement, active immunization and passive immunization are mainly used for prevention, but there were still cases of incidence after prevention. With the development of passive immune agents, new research evidence has emerged. On the basis of debridement and active immunization, rational use of passive immune agents may further reduce the risk of disease and the occurrence of adverse reactions. Based on the Standard for Diagnosis and Treatment of Non-neonatal Tetanus (2024 edition) issued by National Health Commission of the People's Republic of China, experts in the field were organized by Animal Injury Treatment Branch of China Medical Rescue Association, and Animal Injury and Acute Infectious Disease Prevention Branch of Beijing Society of Integrative Medicine. This consensus was developed by referring to the guidelines and consensus, combined with the clinical experience of experts.
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