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Clinical Manifestations.

Juan-Camilo Vargas-González1,2, Hessah A Alotibi1, Kasey Cortez2

  • 1Memory Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

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Summary
This summary is machine-generated.

Informant characteristics like sex and visit frequency significantly impact dementia severity staging in frontotemporal dementia (FTD). Female informants and more frequent visits correlate with higher CDR PLUS NACC-FTLD scores, similar to Alzheimer's Disease findings.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Clinical Neurology

Background:

  • Disease severity staging in dementia research relies on informant input.
  • The Clinical Dementia Rating Sum of Boxes (CDR) is standard for Alzheimer's Disease (AD) and adapted for frontotemporal lobar degeneration (FTLD) as CDR PLUS NACC-FTLD.
  • Prior studies noted informant effects on CDR in AD; this study investigates this in FTD.

Purpose of the Study:

  • To evaluate the influence of informant characteristics on the CDR PLUS NACC-FTLD staging tool in a large frontotemporal dementia (FTD) cohort.
  • To determine if informant sex, relationship, or visit frequency affects FTD severity scores.
  • To compare findings with informant effects observed in Alzheimer's Disease.

Main Methods:

  • Analysis of a large cohort of participants with FTD-related syndromes from the ALLFTD study.
  • Inclusion criteria: CDR PLUS NACC-FTLD score > 0, available Montreal Cognitive Assessment (MoCA) and Neuropsychiatric Inventory Questionnaire (NPI-Q) data.
  • Conditional growth models using multilevel linear regression, with exploratory stratified analysis by patient sex.

Main Results:

  • 1411 participants and 2063 visits were analyzed.
  • Female informants were associated with higher CDR PLUS NACC-FTLD scores (0.41 higher).
  • Increased visit frequency (daily, weekly) and cohabitation were linked to significantly higher scores; lower MoCA and higher NPI-Q scores also increased scores. Female informants impacted scores only in male patients.

Conclusions:

  • Informant sex and visit frequency demonstrably influence CDR PLUS NACC-FTLD scores in frontotemporal dementia (FTD).
  • Findings mirror those in Alzheimer's Disease, highlighting a consistent informant effect across dementia types.
  • Recognizing informant characteristics is crucial for accurate dementia severity assessment and research in FTD.