Photoinduced Palladium-Catalyzed Controllable Multicomponent Mono- or Di-C-glycosylation for the Construction of
Xin Zhuang1, Xianyu Chen1, Wenming Zhang1
1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China.
Abstract:
A general modular assembly strategy for the selective synthesis of alkyl C-glycoconjugates was reported via a photoinduced Pd-catalyzed multicomponent mono- or di-C-glycosylation from a variety of glycosyl radical precursors, feedstock 1,3-dienes, and readily available carbon-, oxygen-, nitrogen-, and sulfur-based nucleophiles. This protocol features mild conditions, good functional group tolerability, and excellent regio- and stereoselectivities. The strategy also provides a practical platform for the synthesis of diverse valuable C-glycosylated heterocycles, glyco-amino acids, glyco-peptides, glyco-lipids, and glyco-drug derivatives.
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