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Clinical Manifestations.

Guilherme Briczinski Souza1, Daniel Coswig Zitzke1, Gabriela Sanches1

  • 1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.

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Summary
This summary is machine-generated.

This study found that lower reading proficiency in individuals with Alzheimer's disease correlated with higher fundamental frequency in speech. Digital speech markers may offer new insights into reading difficulties in Alzheimer's disease (AD).

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Area of Science:

  • Neurology
  • Speech-Language Pathology

Background:

  • Alzheimer's disease (AD) significantly impacts cognitive functions, including reading and writing.
  • Accurate and efficient assessment tools are crucial for diagnosing AD-related communication deficits and planning rehabilitation.
  • Digital speech markers show promise for evaluating speech and voice tasks, such as reading.

Purpose of the Study:

  • To investigate the relationship between digital speech markers during a reading task and self-reported reading outcomes in Brazilian Portuguese speakers with AD.
  • To explore the utility of speech analysis for assessing reading abilities in individuals with Alzheimer's disease.

Main Methods:

  • Literate individuals diagnosed with Alzheimer's disease (AD) participated in the study.
  • Participants completed a self-report questionnaire on speaking proficiency and reading difficulties.
  • Speech samples were collected using a paragraph reading task via the Toolkit to Examine Lifelike Language (TELL) app.
  • Speech-timing, pitch-related, and voice-quality features were analyzed.
  • Spearman's correlations were used to test associations between speech markers and self-report scores (p < 0.05).

Main Results:

  • The study included 15 individuals with AD.
  • A significant negative correlation was observed between self-reported reading proficiency and fundamental frequency (r = -0.581, p = 0.023).
  • Lower self-reported reading proficiency was associated with higher fundamental frequency.

Conclusions:

  • A potential link exists between the self-perception of reading ability and speech motor control, specifically voice characteristics.
  • These preliminary findings suggest that digital speech markers, like fundamental frequency, could be valuable in assessing reading difficulties in Alzheimer's disease.
  • Further research with larger sample sizes and advanced analyses is warranted to confirm these results and explore confounding factors.